ANTIDIABETIC AND ANTIHYPERLIPIDEMIC EFFECTS OF DIFFERENT PARTS OF OGBONA (Irvingia gabonensis) SEED IN ALLOXAN-INDUCED DIABETIC RATS

Folami S.O.; Pogi I.B.; Lawal A.S.; Sebioniga-Lawal M.Y.; Salihu S.; Adepoju M.O.; Sanni S.

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Research Article
Online Published: 16 Nov 2025

JIRLS. 2025; 7(2): 33-41

ANTIDIABETIC AND ANTIHYPERLIPIDEMIC EFFECTS OF DIFFERENT PARTS OF OGBONA (Irvingia gabonensis) SEED IN ALLOXAN-INDUCED DIABETIC RATS

Folami S.o., Pogi I.b., Lawal A.s., Sebioniga-lawal M.y., Salihu S., Adepoju M.o., Sanni S..

Abstract
Diabetes mellitus remains a significant global health challenge, often leading to weight loss, hyperglycemia, dyslipidemia, and oxidative stress. Irvingia gabonensis (commonly known as Ogbona) is a medicinal plant with ethnobotanical relevance in the management of metabolic disorders. This study aimed to evaluate the antidiabetic and antihyperlipidemic effects of different parts of Ogbona seed—whole, peel, and kernel administered at varying doses in alloxan-induced diabetic rats. Diabetes was induced using alloxan monohydrate (150 mg/kg, i.p.) in albino rats. Experimental groups (n=6) received oral treatments of whole seed (WO), peel (OP), and seed kernel (OS) at doses of 100, 200, and 300 mg/kg body weight for 21 days. Metformin (500 mg/kg) served as the standard drug. Parameters assessed included body weight, fasting blood glucose, total haemoglobin (Hb), glycated haemoglobin (HbA1c), lipid profile (TC, TG, HDL, LDL, VLDL), and atherogenic index (AIX). Alloxan-induced diabetic rats showed significant weight loss, hyperglycemia (14.59 ± 1.21 mmol/L), decreased Hb (8.49 ± 0.47 g/dL), increased HbA1c (8.06 ± 0.68%), and elevated lipid profile. Treatment with Ogbona significantly (p<0.05) restored body weight and improved all biochemical indices. The 300 mg/kg doses of WO₃ and OP₃ notably reduced glucose to 5.32 ± 0.40 and 5.10 ± 0.18 mmol/L respectively, and normalized HbA1c levels (4.88–4.63%). Lipid parameters and AIX were significantly lowered, with improved HDL and reduced LDL levels, comparable to metformin.
The study confirms the potent antidiabetic and antihyperlipidemic effects of Irvingia gabonensis, particularly at higher doses of the whole and peel forms, validating its traditional use and supporting its development as a phytotherapeutic agent in diabetes management.

Key words: Irvingia gabonensis, diabetes, lipid profile, blood glucose, haemoglobin, atherogenic index

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Pubmed Style

S.o. F, I.b. P, A.s. L, M.y. S, S. S, M.o. A, S. S. ANTIDIABETIC AND ANTIHYPERLIPIDEMIC EFFECTS OF DIFFERENT PARTS OF OGBONA (Irvingia gabonensis) SEED IN ALLOXAN-INDUCED DIABETIC RATS. JIRLS. 2025; 7(2): 33-41.

Web Style

S.o. F, I.b. P, A.s. L, M.y. S, S. S, M.o. A, S. S. ANTIDIABETIC AND ANTIHYPERLIPIDEMIC EFFECTS OF DIFFERENT PARTS OF OGBONA (Irvingia gabonensis) SEED IN ALLOXAN-INDUCED DIABETIC RATS. https://www.jirlsonline.com/?mno=297006 [Access: June 27, 2026].

AMA (American Medical Association) Style

S.o. F, I.b. P, A.s. L, M.y. S, S. S, M.o. A, S. S. ANTIDIABETIC AND ANTIHYPERLIPIDEMIC EFFECTS OF DIFFERENT PARTS OF OGBONA (Irvingia gabonensis) SEED IN ALLOXAN-INDUCED DIABETIC RATS. JIRLS. 2025; 7(2): 33-41.

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Harvard Style

S.o., F., I.b., . P., A.s., . L., M.y., . S., S., . S., M.o., . A. & S., . S. (2025) ANTIDIABETIC AND ANTIHYPERLIPIDEMIC EFFECTS OF DIFFERENT PARTS OF OGBONA (Irvingia gabonensis) SEED IN ALLOXAN-INDUCED DIABETIC RATS. JIRLS, 7 (2), 33-41.

Turabian Style

S.o., Folami, Pogi I.b., Lawal A.s., Sebioniga-lawal M.y., Salihu S., Adepoju M.o., and Sanni S.. 2025. ANTIDIABETIC AND ANTIHYPERLIPIDEMIC EFFECTS OF DIFFERENT PARTS OF OGBONA (Irvingia gabonensis) SEED IN ALLOXAN-INDUCED DIABETIC RATS. Journal of Innovative Research in Life Sciences, 7 (2), 33-41.

Chicago Style

S.o., Folami, Pogi I.b., Lawal A.s., Sebioniga-lawal M.y., Salihu S., Adepoju M.o., and Sanni S.. "ANTIDIABETIC AND ANTIHYPERLIPIDEMIC EFFECTS OF DIFFERENT PARTS OF OGBONA (Irvingia gabonensis) SEED IN ALLOXAN-INDUCED DIABETIC RATS." Journal of Innovative Research in Life Sciences 7 (2025), 33-41.

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