IDENTIFICATION OF PHARMACOLOGICAL TARGETS OF 5-METHYL COUMARIN-4Β-GLUCOSIDE BY COMPUTATIONAL TARGET FISHING

Alhassan MA and Ibrahim M.

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Research Article

JIRLS. 2021; 3(1): 15-21

IDENTIFICATION OF PHARMACOLOGICAL TARGETS OF 5-METHYL COUMARIN-4Β-GLUCOSIDE BY COMPUTATIONAL TARGET FISHING

Alhassan MA and Ibrahim M..

Abstract
Vernonia glaberrimais a shrub that grows in Nigeria and other West African countries. It is used in folk medicine for the treatment of different ailments. This plant contains5-methyl coumarin-4β-glucosidein very large quantity. Despite the abundance of these natural products its biochemical mechanism of actions and potential molecular targets are yet to be identified. In this research work, we identified the likely molecular targets of this compound using Pharm Mapper, Swiss Target Prediction and molecular docking. Two enzymes namely, carbonic anhydrase 2 and 12 were found to be the most probable disease related targets. The present study provides information on potential therapeutic targets of 5-methyl coumarin-4β-glucoside for future drug development.

Key words: Vernonia glaberrima, 5-methyl coumarin-4β-glucoside, Pharmacological Targets, docking, carbonic anhydrase

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Pubmed Style

Alhassan MA and Ibrahim M.. IDENTIFICATION OF PHARMACOLOGICAL TARGETS OF 5-METHYL COUMARIN-4Β-GLUCOSIDE BY COMPUTATIONAL TARGET FISHING . JIRLS. 2021; 3(1): 15-21.

Web Style

Alhassan MA and Ibrahim M.. IDENTIFICATION OF PHARMACOLOGICAL TARGETS OF 5-METHYL COUMARIN-4Β-GLUCOSIDE BY COMPUTATIONAL TARGET FISHING . https://www.jirlsonline.com/?mno=26193 [Access: January 08, 2024].

AMA (American Medical Association) Style

Alhassan MA and Ibrahim M.. IDENTIFICATION OF PHARMACOLOGICAL TARGETS OF 5-METHYL COUMARIN-4Β-GLUCOSIDE BY COMPUTATIONAL TARGET FISHING . JIRLS. 2021; 3(1): 15-21.

Vancouver/ICMJE Style

Alhassan MA and Ibrahim M.. IDENTIFICATION OF PHARMACOLOGICAL TARGETS OF 5-METHYL COUMARIN-4Β-GLUCOSIDE BY COMPUTATIONAL TARGET FISHING . JIRLS. (2021), [cited January 08, 2024]; 3(1): 15-21.

Harvard Style

Alhassan MA and Ibrahim M. (2021) IDENTIFICATION OF PHARMACOLOGICAL TARGETS OF 5-METHYL COUMARIN-4Β-GLUCOSIDE BY COMPUTATIONAL TARGET FISHING . JIRLS, 3 (1), 15-21.

Turabian Style

Alhassan MA and Ibrahim M.. 2021. IDENTIFICATION OF PHARMACOLOGICAL TARGETS OF 5-METHYL COUMARIN-4Β-GLUCOSIDE BY COMPUTATIONAL TARGET FISHING . Journal of Innovative Research in Life Sciences, 3 (1), 15-21.

Chicago Style

Alhassan MA and Ibrahim M.. "IDENTIFICATION OF PHARMACOLOGICAL TARGETS OF 5-METHYL COUMARIN-4Β-GLUCOSIDE BY COMPUTATIONAL TARGET FISHING ." Journal of Innovative Research in Life Sciences 3 (2021), 15-21.

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Alhassan MA and Ibrahim M. (2021) IDENTIFICATION OF PHARMACOLOGICAL TARGETS OF 5-METHYL COUMARIN-4Β-GLUCOSIDE BY COMPUTATIONAL TARGET FISHING . Journal of Innovative Research in Life Sciences, 3 (1), 15-21.


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