Abstract
Abstract
Background: The bacterial pathogen Staphylococcus aureus is one of the most well-known and extensively distributed in the globe, responsible for hundreds of thousands to millions of more dangerous invasive infections. In the twenty-first century, one of the most persistent public health issues is antibiotic resistance, a serious and rapidly evolving phenomenon in modern medicine brought on by antibiotic pressure. The objective of this research was to detect antibiotic resistance characteristics in S aureus isolates obtained from wound infections in the orthopedic unit at Federal Medical Centre. Kinshan Kebbi
Methods: 30 presumptive Staphylococcal isolates were obtained from wound samples that the laboratory scientist collected from the orthopedic wards of the Federal Medical Centre Birnin Kebbi isolated and processed. These isolates were then confirmed through standard microbiological procedures, including the use of coagulase, gram staining, Mannitol Salt Agar, and catalase tests. Antibiotic susceptibility testing of S aureus was conducted using Kirby Bauer disc diffusion methods according to EUCAST.
Results: (66.6 %) of the S. aureus isolates were obtained from the 30 presumptive Staphylococcal isolates. The isolates exhibited high rates of resistance to Fusidic acid (100%), Erythromycin (65%), Tigecycline (60%) and low resistance to Linezolid (40%) and Gentamicin (35%).75% of the S aureus isolates were multidrug resistance.
Conclusion: a high proportion of the studied Staphylococcus aureus isolates are resistance to the antibiotics used in this study especially Fusidic acid which call for prompt antibiotic stewardship and preventive strategies to limit the spread of antibiotic resistance isolates in both clinical and community settings.

Key words: KEYWORDS: Staphylococcus aureus, antibiotic resistance phenotypes, multidrug resistance,