E-ISSN 2756-4053 | ISSN 2705-3156
 
2026, Vol: 8, Issue: 2
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Research Article
Online Published: 11 Nov 2026
 


ANTIDIABETIC PROPERTIES OF THE COMBINED EXTRACTS OF Balanites aegyptiaca FRUITS AND Allium cepa LEAVES IN A HIGH-SUCROSE INDUCED DIABETIC Drosophila melanogaster MODEL

Abdulhamid Idris, S.w. Hassan, A.i. Umar.


Abstract
Diabetes mellitus is a metabolic disease characterized by high blood sugar that profoundly affects human health and economy. Although there are a plethora of antidiabetic drugs in the market, the efficacy shown by some medicinal plants sometimes outperforms that of synthetic drugs while being more affordable and less toxic. This study was conducted to evaluate the antidiabetic properties of combined Balanities aegyptiaca fruit and Allium cepa leaves using Drosophila melanogaster model. Phytochemical screening, pilot study, biochemical assay was respectively conducted following standard laboratory protocols. In vivo antidiabetic activity of the crude extract was assessed to determine glucose, trehalose and glycogen while the in-vitro Evaluate in-vitro antioxidant capacity using DPPH and FRAP assays. significant difference (P>0.05) in the fly survival between various concentration of combined Balanities aegyptiaca fruit and Allium cepa leaves and the normal control seven days post treatment. However, there was a gradual decrease in size of the fly beyond seven days when compared with the control. Conversely, there was also no significant difference (P>0.05) between all treated group and the normal control at 14days. Significant increase (P<0.05) was observed in the climbing (locomotor) activity of normal flies, drug control and extract treated diabetic group at higher dosage compared with induced untreated control. Significant increase (p>0.05) was observed in glucose, glycogen and trehalose of diabetic flies treated with extracts when compared with drug and normal control.

Key words: Diabetes mellitus, Antidiabetic, Balanities aegyptiaca, Allium cepa, Drosophila melanogaster.


 
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Pubmed Style

Idris A, Hassan S, Umar A. ANTIDIABETIC PROPERTIES OF THE COMBINED EXTRACTS OF Balanites aegyptiaca FRUITS AND Allium cepa LEAVES IN A HIGH-SUCROSE INDUCED DIABETIC Drosophila melanogaster MODEL. JIRLS. 2026; 8(2): 22-30.

Web Style

Idris A, Hassan S, Umar A. ANTIDIABETIC PROPERTIES OF THE COMBINED EXTRACTS OF Balanites aegyptiaca FRUITS AND Allium cepa LEAVES IN A HIGH-SUCROSE INDUCED DIABETIC Drosophila melanogaster MODEL. https://www.jirlsonline.com/?mno=340381 [Access: November 11, 2026].

AMA (American Medical Association) Style

Idris A, Hassan S, Umar A. ANTIDIABETIC PROPERTIES OF THE COMBINED EXTRACTS OF Balanites aegyptiaca FRUITS AND Allium cepa LEAVES IN A HIGH-SUCROSE INDUCED DIABETIC Drosophila melanogaster MODEL. JIRLS. 2026; 8(2): 22-30.


Vancouver/ICMJE Style

Idris A, Hassan S, Umar A. ANTIDIABETIC PROPERTIES OF THE COMBINED EXTRACTS OF Balanites aegyptiaca FRUITS AND Allium cepa LEAVES IN A HIGH-SUCROSE INDUCED DIABETIC Drosophila melanogaster MODEL. JIRLS. (2026), [cited November 11, 2026]; 8(2): 22-30.


Harvard Style

Idris, A., Hassan, . S. & Umar, . A. (2026) ANTIDIABETIC PROPERTIES OF THE COMBINED EXTRACTS OF Balanites aegyptiaca FRUITS AND Allium cepa LEAVES IN A HIGH-SUCROSE INDUCED DIABETIC Drosophila melanogaster MODEL. JIRLS, 8 (2), 22-30.


Turabian Style

Idris, Abdulhamid, S.w. Hassan, and A.i. Umar. 2026. ANTIDIABETIC PROPERTIES OF THE COMBINED EXTRACTS OF Balanites aegyptiaca FRUITS AND Allium cepa LEAVES IN A HIGH-SUCROSE INDUCED DIABETIC Drosophila melanogaster MODEL. Journal of Innovative Research in Life Sciences, 8 (2), 22-30.


Chicago Style

Idris, Abdulhamid, S.w. Hassan, and A.i. Umar. "ANTIDIABETIC PROPERTIES OF THE COMBINED EXTRACTS OF Balanites aegyptiaca FRUITS AND Allium cepa LEAVES IN A HIGH-SUCROSE INDUCED DIABETIC Drosophila melanogaster MODEL." Journal of Innovative Research in Life Sciences 8 (2026), 22-30.


MLA (The Modern Language Association) Style

Idris, Abdulhamid, S.w. Hassan, and A.i. Umar. "ANTIDIABETIC PROPERTIES OF THE COMBINED EXTRACTS OF Balanites aegyptiaca FRUITS AND Allium cepa LEAVES IN A HIGH-SUCROSE INDUCED DIABETIC Drosophila melanogaster MODEL." Journal of Innovative Research in Life Sciences 8.2 (2026), 22-30. Print.


APA (American Psychological Association) Style

Idris, A., Hassan, . S. & Umar, . A. (2026) ANTIDIABETIC PROPERTIES OF THE COMBINED EXTRACTS OF Balanites aegyptiaca FRUITS AND Allium cepa LEAVES IN A HIGH-SUCROSE INDUCED DIABETIC Drosophila melanogaster MODEL. Journal of Innovative Research in Life Sciences, 8 (2), 22-30.



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