ANTI-DIABETIC ACTIVITY OF METHANOL LEAF EXTRACT OF HOSLUNDIA OPPOSITE IN ALLOXAN-INDUCED DIABETIC RATS

Sulaimon Olayiwola Folami; Mujidat Omobolanle Adepoju; Ibrahim Abuga; Balogun Morufu Eyitayo; Muinat Olanike Kazeem; Giwa-Ajeniya A.O.; Abiodun Sebioniga Lawal; Sherif Salihu; Abdullateef Abayomi Alabi

2025, Vol: 7, Issue: 1

7 / 1Current Issue Online First Archive Aims and Scope Abstracting & Indexing Most Accessed Articles Most Downloaded Articles Most Cited Articles

« Previous Article

Research Article
Online Published: 26 Jan 2025

JIRLS. 2025; 7(1): 30-34

ANTI-DIABETIC ACTIVITY OF METHANOL LEAF EXTRACT OF HOSLUNDIA OPPOSITE IN ALLOXAN-INDUCED DIABETIC RATS

Sulaimon Olayiwola Folami, Mujidat Omobolanle Adepoju, Ibrahim Abuga, Balogun Morufu Eyitayo, Muinat Olanike Kazeem, Giwa-ajeniya A.o., Abiodun Sebioniga Lawal, Sherif Salihu, Abdullateef Abayomi Alabi.

Abstract
Over 10 decades, diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia, oxidative stress, and progressive pancreatic β-cell dysfunction. The limitations of conventional anti-diabetic therapies necessitate the search for plant-based alternatives with minimal side effects. This study investigated the anti-diabetic activity of the methanol leaf extract of Hoslundia opposita in alloxan-induced diabetic rats. The study employed a controlled experimental design involving five groups of male Wistar rats: normal control, diabetic control, and diabetic rats treated with Hoslundia opposita extract (100 mg/kg and 200 mg/kg) or glibenclamide (5 mg/kg). Diabetes was induced using a single intraperitoneal injection of alloxan (120 mg/kg body weight), and the treatments were administered orally for 28 days. Key parameters assessed included fasting blood glucose (FBG) levels, body weight, oxidative stress markers (SOD, CAT, and MDA), and pancreatic histology. The results revealed a dose-dependent reduction in fasting blood glucose levels, with the 200 mg/kg dose achieving a 53% reduction comparable to glibenclamide (55%). Treated groups also exhibited improved body weight and significantly enhanced SOD and CAT activities, alongside reduced MDA levels. Histological analysis demonstrated β-cell regeneration and preservation in treated groups. These effects are attributed to the presence of bioactive compounds in Hoslundia opposita with hypoglycemic and antioxidant properties. This study highlights the therapeutic potential of Hoslundia opposita as a natural remedy for diabetes management. Further studies are recommended to elucidate its molecular mechanisms and evaluate its clinical applicability.

Key words: Hoslundia opposita, diabetes mellitus, alloxan-induced diabetic rats, methanol extract, oxidative stress, pancreatic β-cells, natural remedies.

	ARTICLE TOOLS
	Abstract
	PDF Fulltext
	How to cite this article
	Citation Tools
	Related Records
	Articles by Sulaimon Olayiwola Folami Articles by Mujidat Omobolanle Adepoju Articles by Ibrahim Abuga Articles by Balogun Morufu Eyitayo Articles by Muinat Olanike Kazeem Articles by Giwa-Ajeniya A.O. Articles by Abiodun Sebioniga Lawal Articles by Sherif Salihu Articles by Abdullateef Abayomi Alabi
	on Google
	on Google Scholar

How to Cite this Article

Pubmed Style

Folami SO, Adepoju MO, Abuga I, Eyitayo BM, Kazeem MO, A.o. G, Lawal AS, Salihu S, Alabi AA. ANTI-DIABETIC ACTIVITY OF METHANOL LEAF EXTRACT OF HOSLUNDIA OPPOSITE IN ALLOXAN-INDUCED DIABETIC RATS. JIRLS. 2025; 7(1): 30-34.

Web Style

Folami SO, Adepoju MO, Abuga I, Eyitayo BM, Kazeem MO, A.o. G, Lawal AS, Salihu S, Alabi AA. ANTI-DIABETIC ACTIVITY OF METHANOL LEAF EXTRACT OF HOSLUNDIA OPPOSITE IN ALLOXAN-INDUCED DIABETIC RATS. https://www.jirlsonline.com/?mno=239881 [Access: January 27, 2025].

AMA (American Medical Association) Style

Folami SO, Adepoju MO, Abuga I, Eyitayo BM, Kazeem MO, A.o. G, Lawal AS, Salihu S, Alabi AA. ANTI-DIABETIC ACTIVITY OF METHANOL LEAF EXTRACT OF HOSLUNDIA OPPOSITE IN ALLOXAN-INDUCED DIABETIC RATS. JIRLS. 2025; 7(1): 30-34.

Vancouver/ICMJE Style

Harvard Style

Folami, S. O., Adepoju, . M. O., Abuga, . I., Eyitayo, . B. M., Kazeem, . M. O., A.o., . G., Lawal, . A. S., Salihu, . S. & Alabi, . A. A. (2025) ANTI-DIABETIC ACTIVITY OF METHANOL LEAF EXTRACT OF HOSLUNDIA OPPOSITE IN ALLOXAN-INDUCED DIABETIC RATS. JIRLS, 7 (1), 30-34.

Turabian Style

Folami, Sulaimon Olayiwola, Mujidat Omobolanle Adepoju, Ibrahim Abuga, Balogun Morufu Eyitayo, Muinat Olanike Kazeem, Giwa-ajeniya A.o., Abiodun Sebioniga Lawal, Sherif Salihu, and Abdullateef Abayomi Alabi. 2025. ANTI-DIABETIC ACTIVITY OF METHANOL LEAF EXTRACT OF HOSLUNDIA OPPOSITE IN ALLOXAN-INDUCED DIABETIC RATS. Journal of Innovative Research in Life Sciences, 7 (1), 30-34.

Chicago Style

Folami, Sulaimon Olayiwola, Mujidat Omobolanle Adepoju, Ibrahim Abuga, Balogun Morufu Eyitayo, Muinat Olanike Kazeem, Giwa-ajeniya A.o., Abiodun Sebioniga Lawal, Sherif Salihu, and Abdullateef Abayomi Alabi. "ANTI-DIABETIC ACTIVITY OF METHANOL LEAF EXTRACT OF HOSLUNDIA OPPOSITE IN ALLOXAN-INDUCED DIABETIC RATS." Journal of Innovative Research in Life Sciences 7 (2025), 30-34.

MLA (The Modern Language Association) Style

Folami, Sulaimon Olayiwola, Mujidat Omobolanle Adepoju, Ibrahim Abuga, Balogun Morufu Eyitayo, Muinat Olanike Kazeem, Giwa-ajeniya A.o., Abiodun Sebioniga Lawal, Sherif Salihu, and Abdullateef Abayomi Alabi. "ANTI-DIABETIC ACTIVITY OF METHANOL LEAF EXTRACT OF HOSLUNDIA OPPOSITE IN ALLOXAN-INDUCED DIABETIC RATS." Journal of Innovative Research in Life Sciences 7.1 (2025), 30-34. Print.

APA (American Psychological Association) Style

About Journal of Innovative Research in Life Sciences

Contact Information

How to cite this article


About Journal of Innovative Research in Life Sciences Journal of Innovative Research in Life Sciences (JIRLS) is published by the Faculty of Life Sciences Kebbi State University of Science and Technology, Ali ... Read more. For best results, please use Internet Explorer or Google Chrome.	Contact Information The Editor - in - Chief Journal of Innovative Research in Life Sciences Faculty of Life Sciences KSUST, Aliero P.M.B. 1144 Birnin Kebbi, Kebbi State, Nigeria Tel No: +2348037731851, +2348038688681 e-mail addresses: editor.jirls@gmail.com website: www.jirlsonline.com