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2024, Vol: 6, Issue: 2
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Review Article
Online Published: 30 Dec 2024
 


ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM)

Alkanchi N.A., Salihu S., Sidi J.U.


Abstract
The main risk factors for the development of gestational diabetes mellitus (GDM) are age, lifestyle, and diet. The pathogenesis of GDM is characterized by β-cell dysfunction and insulin resistance (IR). As a result of IR's indirect impact on important metabolic enzymes, diabetic people are also more susceptible to aberrant cholesterol and lipoprotein levels. Recent research, however, raised the possibility that lipid alterations might really be the cause of poor glucose metabolism rather than just a symptom of it. The fluidity and permeability of cell membranes, as well as the translocation of glucose transporters and insulin receptor binding and signaling, are all influenced by free fatty acids (FFAs). Thus, it is hypothesized that FFAs may be crucial in the emergence of IR and GDM. The purpose of the current review was to examine FFAs' roles in the pathogenesis of GDM, as it has yet to be fully elucidated.

Key words: Gestational Diabetes Mellitus (GDM), Oxidative stress, insulin Resistance, Free fatty acids, Insulin signaling.


 
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How to Cite this Article
Pubmed Style

Alkanchi N.A., Salihu S., Sidi J.U. ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM). JIRLS. 2024; 6(2): 79-85.

Web Style

Alkanchi N.A., Salihu S., Sidi J.U. ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM). https://www.jirlsonline.com/?mno=235397 [Access: December 31, 2024].

AMA (American Medical Association) Style

Alkanchi N.A., Salihu S., Sidi J.U. ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM). JIRLS. 2024; 6(2): 79-85.


Vancouver/ICMJE Style

Alkanchi N.A., Salihu S., Sidi J.U. ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM). JIRLS. (2024), [cited December 31, 2024]; 6(2): 79-85.


Harvard Style

Alkanchi N.A., Salihu S., Sidi J.U (2024) ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM). JIRLS, 6 (2), 79-85.


Turabian Style

Alkanchi N.A., Salihu S., Sidi J.U. 2024. ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM). Journal of Innovative Research in Life Sciences, 6 (2), 79-85.


Chicago Style

Alkanchi N.A., Salihu S., Sidi J.U. "ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM)." Journal of Innovative Research in Life Sciences 6 (2024), 79-85.


MLA (The Modern Language Association) Style

Alkanchi N.A., Salihu S., Sidi J.U. "ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM)." Journal of Innovative Research in Life Sciences 6.2 (2024), 79-85. Print.


APA (American Psychological Association) Style

Alkanchi N.A., Salihu S., Sidi J.U (2024) ROLE OF FREE FATTY ACIDS IN THE PATHOGENESIS OF GESTATIONAL DIABETES MELLITUS (GDM). Journal of Innovative Research in Life Sciences, 6 (2), 79-85.


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