Gastroprotective Activity of Ethanolic Extract of Raphia mambillensis Seeds on Indomethacin- induced Ulcerated Wistar Rats

Azeemat Titilola Abdulazeez; Fatimah Aluko Abubakar

2024, Vol: 6, Issue: 2

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Research Article

JIRLS. 0; 0(0):

Gastroprotective Activity of Ethanolic Extract of Raphia mambillensis Seeds on Indomethacin- induced Ulcerated Wistar Rats

Azeemat Titilola Abdulazeez, Fatimah Aluko Abubakar.

Abstract
Raphia mambillensis (Raffia palm) seeds are traditionally used in South Western Nigeria to treat different ailments including gastrointestinal-related disorders. This study aimed to assess the gastroprotective activity of Ethanolic Extract of Raphia mambillensis seeds (EERMS). Animals were pre-treated orally with different doses of EERMS and reference drug (ranitidine) for 5 days and then induced for gastric ulceration using indomethacin (10mg/kg body weight) for 3 days. At the end of the experiment, various indices of gastric secretion were assessed. EERMS (50mg and 100mg/kg b.w.) significantly (P < 0.05) reduced the severity of indomethacin-induced gastric mucosal damage as shown by the reduced ulcer index, gastric acidity, and gastric volume of treated groups when compared with the untreated group. This is highly comparable with the group treated with the reference drug. The presence of a high concentration of Phenolics, Tannins, and antioxidant minerals may be attributed to the antiulcerogenic activity of EERMS. The results suggest that the EERMS confers protection on the gastric tissue against indomethacin-induced ulcerated rats.

Key words: Raphia mambillensis, ranitidine, mucosal damage, ulcer index, indomethacin

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Pubmed Style

Abdulazeez AT, Abubakar FA. Gastroprotective Activity of Ethanolic Extract of Raphia mambillensis Seeds on Indomethacin- induced Ulcerated Wistar Rats. JIRLS. 0; 0(0): 0-0.

Web Style

Abdulazeez AT, Abubakar FA. Gastroprotective Activity of Ethanolic Extract of Raphia mambillensis Seeds on Indomethacin- induced Ulcerated Wistar Rats. https://www.jirlsonline.com/?mno=119419 [Access: January 07, 2024].

AMA (American Medical Association) Style

Abdulazeez AT, Abubakar FA. Gastroprotective Activity of Ethanolic Extract of Raphia mambillensis Seeds on Indomethacin- induced Ulcerated Wistar Rats. JIRLS. 0; 0(0): 0-0.

Vancouver/ICMJE Style

Abdulazeez AT, Abubakar FA. Gastroprotective Activity of Ethanolic Extract of Raphia mambillensis Seeds on Indomethacin- induced Ulcerated Wistar Rats. JIRLS. (0), [cited January 07, 2024]; 0(0): 0-0.

Harvard Style

Abdulazeez, A. T. & Abubakar, . F. A. (0) Gastroprotective Activity of Ethanolic Extract of Raphia mambillensis Seeds on Indomethacin- induced Ulcerated Wistar Rats. JIRLS, 0 (0), 0-0.

Turabian Style

Abdulazeez, Azeemat Titilola, and Fatimah Aluko Abubakar. 0. Gastroprotective Activity of Ethanolic Extract of Raphia mambillensis Seeds on Indomethacin- induced Ulcerated Wistar Rats. Journal of Innovative Research in Life Sciences, 0 (0), 0-0.

Chicago Style

Abdulazeez, Azeemat Titilola, and Fatimah Aluko Abubakar. "Gastroprotective Activity of Ethanolic Extract of Raphia mambillensis Seeds on Indomethacin- induced Ulcerated Wistar Rats." Journal of Innovative Research in Life Sciences 0 (0), 0-0.

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Abdulazeez, A. T. & Abubakar, . F. A. (0) Gastroprotective Activity of Ethanolic Extract of Raphia mambillensis Seeds on Indomethacin- induced Ulcerated Wistar Rats. Journal of Innovative Research in Life Sciences, 0 (0), 0-0.


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